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Unlocking the microbiome(s)


'We are drowning in a sea of data and thirsting for knowledge. Most biology today is low input, high-throughput, and no output biology' – S. Brenner   We try to fix that!

'Life is a program written in DNA' – C. Venter   We make the most out of this program!

Who are we?

Biomathematica is a pioneering company in the application of mathematics to complex biological systems such as the human microbiome.

What do we do?

At Biomathematica, we believe mathematics has the power to revolutionize biology. We have developed a Systems Biology approach to characterize, predict, engineer, control and optimize simple and complex microbial communities. From metagenomic data analysis to strain optimization, engineering of metabolic pathways and personalized microbiome simulations, BioMathematica wants to transform the microbiome field.

Our Services

Bioinformatics ('omics')

We proposose end-to-end bioinformatics pipelines for Next Generation Sequencing data (NGS): amplicon sequencing (16S/18S/ITS), shotgun metagenomics (short and long reads), metatranscriptomics, metabolomics and metaproteomics. We analyze these data using biostatistics, expertise and, if needed, Artificial Intelligence algorithms (e.g. machine learning). We start from raw data (e.g. fasta/fastq files) up to a complete analysis report.

Strains simulations & engineering

We create and use pipelines and models for the development of probiotics / prebiotics / synbiotics and live biotherapeutics targeting the human microbiome, as well as to engineer bacteria strains or consortia targeting the animal, environmental and artificial microbiome(s), or to design new metabolic pathways for the production of new metabolites.


We have developed several models of complex microbial communities (e.g. the human gut microbiome) and use them for the development of therapeutics or microbiome-related compounds (e.g. skincare products targeting the human skin microbiome). These models can be applied to various microbiomes such as the animal, the environmental and the industrial microbiomes.

R & D

We propose made-to-measure R & D projects related to the development of mathematical models or bioinformatics pipelines. For example, these projects can be the development of pharmacokinetics/pharmacodynamics models for drugs targeting the human microbiome.


To share our expertise in bioinformatics and Systems Biology, we propose made-to-measure trainings related to the development of R, python, Matlab, AWS and bash/unix pipelines.

Our clients and collaborators

Our grants and labels

Thinking about a project?
Let's talk.

© 2023 Biomathematica. All rights reserved.


Biomathematica's blog.

Posted by Ghjuvan Grimaud
May 2, 2020

COVID-19 outbreak.

In the past few weeks, we've been engaged in the fight against the COVID-19. We decided to show our support to all the medical staff by buying 96 serological tests of the SARS-Cov-2...

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Posted by Ghjuvan Grimaud
February 15, 2020

Welcoming the PhD candidate Amandine Paulay.

Amandine Paulay recently started her PhD thesis, co-supervised by Biomathematica and...

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Posted by Ghjuvan Grimaud
December 19, 2019

Recap of this year's conferences.

This year has been intense and rich...

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Posted by Ghjuvan Grimaud
December 15, 2019

Welcoming the bioinformatician Florian Specque in our team.

Today, we welcome an enthusiastic bioinformatician...

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Posted by Ghjuvan Grimaud
June 13, 2019

Recipient of the BPI Deeptech Label.

It is our great pleasure to be the recipient of the BPI Deep-tech label...

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Posted by Ghjuvan Grimaud
September, 2018

Joining the Rebelbio accelerator at the Imperial College.

We are delighted to be part of Rebelbio 6th cohort...

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Thinking about a project?
Let's talk.

© 2023 Biomathematica. All rights reserved.

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Rue Des Aloes, Quartier Balestrino
20000 Ajaccio, Corse-du-Sud
Tel. +353 0871 425 186